Search results for "hybrid EMT"

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Adipose stromal cells promote the transition of colorectal cancer cells toward a mesenchymal-like phenotype

2021

ABSTRACT Colon cancer progression is among the risks that increase with obesity. We have recently unveiled the molecular mechanism by which adipose tissue-released molecules, HGF and IL-6, make colorectal cancer (CRC) cells acquiring mesenchymal traits. Targeting of adipose-derived factors abrogate the metastatic potential of CRC stem cells (CR-CSCs) in obese patients.

cancer stem cellCancer ResearchStromal cellTransition (genetics)Colorectal cancerbusiness.industryadipose stromal cellMesenchymal stem cellAdipose tissuecolorectal cancermedicine.diseasePhenotypedigestive system diseaseshybrid EMTCommentaryMolecular mechanismCancer researchmedicineMolecular MedicineSettore MED/46 - Scienze Tecniche Di Medicina Di LaboratorioStem cellbusinessobesity.Article CommentaryMolecular & Cellular Oncology

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